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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 17
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Research Articles

In vivo effects of PCB-126 and genistein on vitellogenin expression in zebrafish

Patrizia LicataDepartment of Veterinary Science, Veterinary Pharmacology and Toxicology, University of Messina, Messina, Italy
,
Roberta TardugnoDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
,
Simona PergolizziDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
,
Gioele CapilloDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
,
Marialuisa AragonaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
,
Antonio ColomboAzienda Sanitaria Provinciale Messina (ASP), Messina, Italy
,
Teresa GervasiDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
,
Vito PellizzeriDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
,
Nicola CiceroDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy;Science4Life s.r.l., A Spin-off of the University of Messina, Messina, ItalyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-8055-1915
ORCID Icon &
Margherita CalòDepartment of Veterinary Science, Veterinary Pharmacology and Toxicology, University of Messina, Messina, Italy
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Pages 2507-2514 | Received 14 Feb 2018, Accepted 11 Mar 2018, Published online: 02 Apr 2018
 
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Abstract

In this study, the vitellogenin (Vtg) modulation by genistein and polychlorinated biphenyl-126 (PCB-126) exposure in zebrafishes has been investigated. Both PCB-126 and genistein have been identified as aquatic pollutants and can further increase estrogenicity of waterways. Vtg is egg yolk precursor protein release by the hepatocytes during vitellogenesis. This process occurs normally in the hepatocytes in response to the activation with the estrogens such as 17-β-estradiol. Our immunohistochemical findings showed a Vtg expression that increases at 12 h and at 72 h in the liver of treated fishes with both PCB-126 and genistein, individually and in combination. Furthermore, for the first time, also hepatic stellate cells (HSC) in the liver parenchyma were strongly positive for vitellogenin.

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