Five macrocyclic glycosides from Schoenoplectus tabernaemontani

Abstract

Macrocyclic glycosides with unique 22-membered dimeric lactone skeleton, are rare occurring natural products. There are only ten compounds reported so far. Herein we reported the isolation and characterisation of five macrocyclic glycosides from Schoenoplectus tabernaemontani, including three new compounds (Schoenopolide A-C, 1–3) and two known ones, Berchemolide (4) and Clemoarmanoside B (5). Their structures were established on the basis of extensive analysis of spectroscopic data. In addition, the anti-oxidative activity of Berchemolide (4) against H₂O₂-induced of renal tubular epithelial (HK-2) cells was also evaluated.

Keywords:

• Cyperaceae
• Schoenoplectus tabernaemontani
• macrocyclic glycosides
• natural products

Acknowledgment

We thank Dr Hong-Ping Long (High Resolution Mass Spectrometry Laboratory in the First Affiliated Hospital of Hunan University of Chinese Medicine) for the HRESIMS measurement and Prof. Guo-Geng Liu (Advanced Research Center in Central South University) for the NMR measurement.