A new flavonoid from the leaves of Atalantia monophylla (L.) DC

Abstract

A new flavonoid, atalantraflavone (1) as well as eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4′-dihydroxy-(3″,4″-dihydro-3″,4″-dihydroxy)-2″,2″-dimethylpyrano-(5″,6″:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer’s disease, acetylcholine esterase (AChE) inhibition and antioxidant activity were evaluated using the modified Ellman’s method and the ABTS scavenging assay, respectively. It was found that isoflavonoid 5, lupalbigenin, showed 79% inhibition to AChE and was 1.4-fold stronger than the tacrine standard. In addition, acridone 7, citrusinine I, displayed 90.68% antioxidant activity.

Keywords:

• Atalanta monophylla
• flavonoid
• acetylcholine esterase
• antioxidant

Acknowledgements

We thank the Thailand Research Fund and Khon Kaen University (RSA5980022) for financial support. We are indebted to The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education, Thailand.