Synthesis of dihydroisorcordoin derivatives and their in vitro anti-oomycete activities

Abstract

A series of novel dihydrochalcone derivatives 2–7 were synthesized from dihydroisorcordoin 1 which was isolated from the aerial parts of Adesmia balsamica. The structures of all compounds were confirmed by ¹H NMR, ¹³C NMR, and HRMS. Their anti-oomycete activity was evaluated in vitro against Saprolegnia parasitica and Saprolegnia diclina. Some of the newly synthesized compounds exhibited better anti-oomycete activities at low values compared with bronopol and fluconazole as positive controls. Among them, compound 7 exhibited strong activity, with minimum inhibitory concentration and minimum oomyceticidal concentration values of 75 and 100 μg/mL, respectively.

Keywords:

• Adesmia balsamica
• dihydroisorcordoin
• anti-oomycete activity
• Saprolegnia sp.

Acknowledgements

The authors thank FONDECYT (grant number 11,140,193) and the Dirección General de Investigación of Universidad de Playa Ancha.