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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 8
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Research Articles

Four new phenolic constituents from the rhizomes of Gastrodia elata Blume

Zhi-Wei WangShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, People’s Republic of China
,
Yun LiShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, People’s Republic of China;College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China
,
Da-Hui LiuInstitute of Medicinal Plants, Yunnan Academy of Agriculture Science, Kunming, People’s Republic of China
,
Yan MuShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, People’s Republic of China
,
Hong-Jing DongShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, People’s Republic of China
,
Hong-Lei ZhouCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China
,
Lan-Ping GuoShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, People’s Republic of China
&
Xiao WangShandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 1140-1146 | Received 07 Feb 2018, Accepted 01 Apr 2018, Published online: 20 Apr 2018
 
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Abstract

Four new gastrodin derivatives containing a trans-cinnamoyl unit (1–4) and nine known compounds (5–13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC50 values of 10.5 and 10.2 μM, respectively.

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