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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 8
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Research Articles

Structurally diverse diterpenoids from Trigonostemon howii

Yan-Ping LiuKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China
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Qing WenKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China
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Shi HuKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China
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Yan-Lei MaKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China
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Zhi-Hua JiangKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China
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Jin-Ying TangKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China
&
Yan-Hui FuKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. ChinaCorrespondence[email protected]
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Pages 1169-1174 | Received 09 Feb 2018, Accepted 04 Apr 2018, Published online: 16 Apr 2018
 
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Abstract

Phytochemical investigation on the stems and leaves of Trigonostemon howii resulted in the isolation of a new abietane diterpenoid, trigohowimine A (1), along with seven known structurally diverse diterpenoids (2–8). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Compound 1 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.82 to 8.53 μM.

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