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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 8
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Research Articles

A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities

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Pages 1175-1181 | Received 09 Feb 2018, Accepted 11 Apr 2018, Published online: 23 Apr 2018
 

Abstract

A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC50 values ranging from 29.0 to 68.0 μM.

Acknowledgement

We thank Dr Yasuko Okamoto (Tokushima Bunri University, Tokushima, Japan) for her technical assistance with the MS measurements.

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