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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 8
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Research Articles

Discovery of a new biphenyl derivative by epigenetic manipulation of marine-derived fungus Aspergillus versicolor

Jing Xuan ZhuLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, China
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Lijian DingLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, China;Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University, Ningbo, ChinaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-2259-9830
ORCID Icon &
Shan HeLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, China;Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University, Ningbo, ChinaCorrespondence[email protected]
Pages 1191-1195 | Received 29 Jan 2018, Accepted 12 Apr 2018, Published online: 23 Apr 2018
 
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Abstract

Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1–3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 μg/mL.

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