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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 9
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Research Articles

Two new steroids with cytotoxicity from the marine sponge Dactylospongia elegans collected from the South China Sea

Jing LiCollege of Pharmacy, Jinan University, Guangzhou, China;Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
,
Zhuo WangResearch Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
,
Fan YangResearch Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
,
Wei-Hua JiaoResearch Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
,
Hou-Wen LinResearch Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaCorrespondence[email protected]
&
Shi-Hai XuCollege of Pharmacy, Jinan University, Guangzhou, ChinaCorrespondence[email protected]
Pages 1340-1344 | Received 02 Feb 2018, Accepted 08 May 2018, Published online: 04 Jun 2018
 
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Abstract

A new steroid, (3S,5R,9R,10S,13R,17R,20R,24S,22E)-ergosta-6,8,22-triene-3,25-diol (1), and its sulfonated analogue (2) together with a known one, 5α,8α-epidioxy-cholest-6-en-3β-ol (3) were isolated from the marine sponge Dactylospongia elegans collected from the South China Sea. The new structures including absolute configurations were established by the HRESIMS and 1D and 2D NMR analysis coupled with the X-ray crystal analysis. Both of 1 and 2 exhibited cytotoxicity against cancer cell line MCF-7 with IC50 values of 9.7 and 8.5 μM, respectively.

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