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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 23
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A new diketopiperazine isolated from a Nocardiopsis strain TRM20105 guided by bioassay against Candida albicans

Haolun ChenKey Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Science, Tarim University, Alar, China
,
Chuanxing WanKey Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Science, Tarim University, Alar, ChinaCorrespondence[email protected]
&
Lili ZhangKey Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, College of Life Science, Tarim University, Alar, China
Pages 3421-3425 | Received 29 Jan 2018, Accepted 06 May 2018, Published online: 05 Jun 2018
 
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Abstract

An actinomycete strain TRM20105 with antifungal activity was identified as Nocardiopsis dassonvillei subsp. dassonvillei DSM43111 (98.34% similarity) by 16S rDNA phylogenetic analysis and morphology observation. The fermentation broth of TRM20105 cultured with oat-soybean medium was subjected to discover bioactive compounds. Guided by antifungal bioassay against Candida albicans, a new diketopiperazine compound was purified via various column chromatographies together with pHPLC. The purified active compound was identified as 1-demethylnocazine A, (3Z,6Z)-5-methoxy-3,6-bis(4-methoxybenzylidene) -1,6-dihydropyrazin-2(3H)-one by the analyses of 1D & 2D NMR data.

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