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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 24
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Research Articles

New hepatoprotective isoflavone glucosides from Pueraria lobata (Willd.) Ohwi

Yingjie Sun Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China
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Hongmin Zhang Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China
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Ming Cheng Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China
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Shijie Cao Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China
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Miao Qiao Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China
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Boli Zhang Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China
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Liqin Ding Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. ChinaCorrespondence[email protected]
&
Feng Qiu Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. China; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine , Tianjin, P.R. ChinaCorrespondence[email protected]
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Pages 3485-3492 | Received 27 Feb 2018, Accepted 29 May 2018, Published online: 03 Jul 2018
 
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Abstract

Two new isoflavone glucosides, 3′-methoxyneopuerarin A (1) and 3′-methoxyneopuerarin B (2), together with nine known isoflavones including puerarin (3), neopuerarin A (4), neopuerarin B (5), daidzin (6), daidzein (7), 3′-methoxypuerarin (PG-3) (8), puerarin xyloside (9), mirificin (10), 3′-hydroxypuerarin (11) were isolated from the water extraction of the dried roots of Pueraria lobata (Willd.) Ohwi. Their structures were elucidated by the means of spectroscopic and chromatographic analysis methods. All compounds were evaluated for their hepatoprotective activity on HepG2 cells. All of them showed statistically significant hepatoprotective effect.

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