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Abstract
Two new monoterpenoid indole alkaloids, tabervarines A (1) and B (2), along with seven known monoterpenoid indole alkaloids, were isolated from the methanol extract of the twigs and leaves of Tabernaemontana divaricata. The structures including the absolute configurations of the new alkaloids were elucidated based on MS, NMR, and ECD calculation. The in vitro cytotoxic activities of the isolated alkaloids against several human cancer cell lines were also evaluated.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
The work was financially supported by the National Natural Science Foundation of China [81473122], the Youth Innovation Promotion Association of CAS [2015323], CAS “Light of West China” Program (to Yu Zhang), the Young Academic and Technical Leader Raising Foundation of Yunnan Province (to Yu Zhang), Yunnan Applied Basic Research Projects (2015FB205-022), and State Key Laboratory of Phytochemistry and Plant Resources in West China (P2016-ZZ08).