Flavone glucosides from Artemisia juncea

Abstract

A new flavone glucoside, 4′,5-dihydroxy-3′,5′,6-trimethoxyflavone-7-O-β-D-glucoside was obtained from aerial parts of Artemisia juncea, together with the known flavone eupatilin (5,7-dihydroxy-3′,4′,6-trimethoxyflavone). The compounds were comprehensively analytically characterized by IR, UV, NMR and HR-MS, and their chemical structures ascertained. The EtOAc fraction of A. juncea showed the strongest DPPH radical scavenging ability as well as reducing power (in CUPRAC and FRAP assays) and phosphomolybdenum activity. This fraction also exhibited the strongest inhibitory effects on tyrosinase. Additionally, the best antidiabetic effects were observed for eupatilin and the CHCl₃ fraction.

Keywords:

• Artemisia juncea
• flavones
• flavonoid
• 4′,5-dihydroxy-3′,5′,6-trimethoxyflavone-7-O-β-D-glucoside
• eupatilin
• antioxidant
• enzyme inhibitor

Acknowledgements

The project was funded through a grant from the Republic of Uzbekistan State Foundation for Basic Research (grant number M/UZB-KNR-25-2015 and TA-FA-F7-008). We gratefully acknowledge Dr. Roland Hellinger (Center for Analytical Chemistry, Department for Agrobiotechnology, BOKU) for measuring the HR-MS spectra.

Disclosure statement

No potential conflict of interest was reported by the authors.