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Abstract
A new abietane diterpenoid glycoside, ajugaside B (1), along with three known compounds (2–4), were isolated from the whole plants of Ajuga ovalifolia var. calantha. The structure of the new compound (1) was elucidated by means of spectroscopic analyses (HRESIMS, IR, NMR and ECD). All of the isolated compounds were evaluated for their antitumor activities against MGC803, MCF-7, A549, HT29 and HepG2 cell lines. Compounds 3–4 showed moderate cytotoxicity against all tested cell lines with IC50 values of 1.8–7.3 μM.
Graphical Abstract
Acknowledgement
We gratefully acknowledge Prof. Cheng Yang of Si Chuan University for measuring CD and the support from Hong yuan County Productivity Promotion Center for collecting plant.
Disclosure statement
No conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the National Natural Science Foundation of China [grant number 81703693, 81774202]; The Youth Science and Technology Innovative Research Team Fund Project of Sichuan [grant number 2016TD0006]; Department of Science and Technology of Sichuan Province [grant number 2016SZYZF0002]; Department of Science and Technology of Chengdu [grant number 2016-HM01-00457-SF]; Education Department of Sichuan Province (grant number 18ZA0181).