A new furan derivative from an endophytic Aspergillus tubingensis of Decaisnea insignis (Griff.) Hook.f. & Thomson

Abstract

A new furan derivative named 3-(5-oxo-2,5-dihydrofuran-3-yl) propanoic acid (1) was isolated for the first time. Its structure was elucidated by UV, IR, NMR, HR-ESI-MS and the single-crystal X-ray diffraction spectroscopic data. Meanwhile, the antifungal and antibacterial activities of compound 1 was tested, it exhibited potent antifungal activity against Fusarium graminearum with MIC value of 16 µg/mL and medium antibacterial activity against Streptococcus lactis with MIC value of 32 µg/mL.

Graphical Abstract

Keywords:

• Furan derivative
• 3-(5-oxo-2,5-dihydrofuran-3-yl) propanoic acid
• Aspergillus tubingensis
• Decaisnea insignis (Griff.) Hook.f. & Thomson

Disclosure statement

No conflict of interest was reported by the authors.

Additional information

Funding

This work was financed by the Natural Science Basic Research Plan in Shaanxi Province of China [grant number 2014JZ003] and Science & Technology Co-ordination & Innovation Project of Shaanxi Province [grant number 2016KTTSNY03-04]. The Natural Science Basic Research Plan in Shaanxi Province of China,Science & Technology Co-ordination & Innovation Project of Shaanxi Province