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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 19
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Research Articles

12β-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata

Peng-Yan GuiKey Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, China; ;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; View further author information
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Xiao-Hui YanCollege of Forestry, Southwest Forestry University/Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, China; ;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; View further author information
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Wen-Juan YuanState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; ;Yunnan Institute for Food and Drug control, Kunming, Yunnan, ChinaView further author information
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Yuan-Liang MaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; View further author information
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Xiao DingState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; View further author information
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Shuai LiuState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; View further author information
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Ying-Tong DiState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; Correspondence[email protected]
View further author information
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Wei-Ming ZhuKey Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, China; Correspondence[email protected]
View further author information
&
Xiao-Jiang HaoState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; View further author information
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Pages 2830-2836 | Received 22 Apr 2018, Accepted 29 Jul 2018, Published online: 03 Nov 2018
 
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Abstract

A new A, D-seco limonoid, named 12-acetyloxyperforatin (1), along with three known ones, were isolated from the leaves of Harrisonia perforata. Their structures were elucidated on the basis of spectroscopic analysis, including extensive NMR techniques and computational modelling. These compounds showed no inhibitory activity against the 11β-HSD1 enzyme.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (21432010, 31770392, and 81573323); Technological leading talent project of Yunnan Province (2015HA020); and Central Asian Drug Discovery and Development Center of Chinese Academy of Sciences (CAM201402 and CAM201302).

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