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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 10
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Research Articles

Two new xanthone glycosides from Swertia punicea Hemsl. and their anti-inflammatory activity

Lin-Yun MouTechnology Center, China Tobacco Yunnan Industrial Co., Ltd, Kunming, P. R. China; ;Key Laboratory of Chemistry in Ethnic Medicinal Resouces, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming, P. R. ChinaView further author information
,
Hai-Yan WuKey Laboratory of Chemistry in Ethnic Medicinal Resouces, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming, P. R. ChinaView further author information
,
En-Guang MaKey Laboratory of Chemistry in Ethnic Medicinal Resouces, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming, P. R. ChinaView further author information
,
Ming-Feng WangTechnology Center, China Tobacco Yunnan Industrial Co., Ltd, Kunming, P. R. China; View further author information
,
Yan-Qing DuanTechnology Center, China Tobacco Yunnan Industrial Co., Ltd, Kunming, P. R. China; View further author information
,
Sheng LeiTechnology Center, China Tobacco Yunnan Industrial Co., Ltd, Kunming, P. R. China; Correspondence[email protected] [email protected]
View further author information
&
Gan-Peng LiKey Laboratory of Chemistry in Ethnic Medicinal Resouces, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming, P. R. ChinaCorrespondence[email protected] [email protected]
View further author information
 show all
Pages 1423-1429 | Received 26 Mar 2018, Accepted 04 Aug 2018, Published online: 20 Nov 2018
 
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Abstract

Two new xanthone glycosides (1–2), together with seven known analogues (3–9), were isolated from whole herb of Swertia punicea. The structures of these metabolites were established on the basis of detailed spectroscopic analysis and comparison with data reported in the literature. In an in vitro test, all isolates were evaluated for their anti-inflammatory activity. The results revealed that all of them showed significant anti-inflammatory activity with IC50 values ranging from 1.237 to 3.319 mM. Compounds 3, 4, and 5 (IC50 values in the range 1.237–1.987 mM) displayed more potent anti-inflammatory activity than the positive control, indomethacin (IC50 value of 2.004 mM).

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Additional information

Funding

This work was financially supported by Technology Center, China Tobacco Yunnan Industrial Co., Ltd [grant number JSZX20151008-52].

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