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Abstract
The diterpene isocoronarin D (1) is a bioactive major constituent of labdane diterpene from the aerial parts of Curcuma comosa Roxb. (Zingiberaceae), the Thai medicinal plant. Microbial transformation of 1 was performed by the fungus Cunninghamella echinulata NRRL 1386 to yield three new metabolites, 3β-hydroxyisocoronarin D (2), 6α-hydroxyisocoronarin D (3) and 3β,7α-dihydroxyisocoronarin D (4). The structures of the new compounds were elucidated by spectroscopic techniques.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by The Thailand Research Fund (grant no. DBG5980003) and the Center of Excellence for Innovation in Chemistry (PERCH-CIC), and Office of the Higher Education Commission.