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Abstract
Two new tetralone glycosides, 4(S)-5-methoxy juglanoside A (1), 4(S)-5-methoxy juglanoside D (2), together with ten known compounds (3–12) have been isolated from the green walnut husks of Juglans mandshurica Maxim. Their structures were elucidated on the basis of their ESI-MS, 1 D and 2 D NMR spectroscopic data. In addition, all compounds were evaluated for their cytotoxic activities against the cancer BGC-823 (human gastric carcinoma), HCT-15 (human colorectal carcinoma) and K562 (human chronic myeloid leukemia) cell lines. The results showed aglycones of naphthoquinones had stronger cytotoxic activities than glycosides of tetralone.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the National Science Foundation of China [grant number 81202890]; China Postdoctoral Science Foundation funded project [grant number 2013M530164 and 2014T70374]; Heilongjiang Postdoctoral Fund [grant number LBH-Z13195 and LBH-Q16207]; and Harbin city youth science and technology innovation talents [grant number 2013RFQXJ052].