A new phenolic glycoside from the Idesia polycarpa Maxim. leaves

Abstract

Phytochemical investigation on the ethyl acetate extract of Idesia polycarpa Maxim. Leaves led to the isolation of four phenolic glycoside isomers (1–4). Compound 2 appeared to be new reported phenolic glycoside, while compound 1 was the first time isolated from the titled species. Their structures were established by IR, UV, HRESI-MS and 1D and 2D NMR spectroscopies analysis and comparison of spectral data with previously reported data. The compounds 3 and 4 showed stronger activity of scavenging the DPPH free radical than the other two compounds, while the compounds 1 and 2 showed a significant activity of scavenging the ABTS free radical. Compounds 2 and 4 exhibited stronger cytotoxicity against HepG2 cell lines compared to compounds 1 and 3. Moreover, compound 3 presented the highest cytotoxicity against MCF cell lines with IC₅₀ value of 37.17 ± 0.26 μg/mL than compounds 1, 2 and 4.

Keywords:

• Idesia polycarpa Maxim.
• phenolic glycoside isomers
• cytotoxicity
• antioxidant

Disclosure statement

The authors declare no competing financial interest.

Additional information

Funding

This work was supported by the project Sichuan Science and Technology Poverty Alleviation [grant number 2016NZYZF] and the project Luzhou Science and Technology [grant number 2016CDLZ-Z20].