A immunosuppressive triterpenoid saponin from the stems of Epigynum griffithianum

Abstract

Chemical investigation of the stems of Epigunum griffithianum led to the isolation and identification of a new triterpenoid saponin (1) and two known compounds (epigynosides A (2) and B (3)). These structures were elucidated by means of spectroscopic analysis (1D and 2D NMR, MS, UV, IR) as well as comparison with the reported data. Compound 1 was evaluated in vitro for the immunosuppressive activities on proliferation of mice splenocyte and displayed significant immunosuppressive activities compared to the positive control (dexamethasone) with the concentration at 25 μM.

Keywords:

• Epigunum griffithianum
• triterpenoid saponin
• immunosuppressive activity

Acknowledgement

This work was financially supported by the Natural Science Foundation of Yunnan Province (grant number 2016FD057).

Disclosure statement

We declare that there is no conflict of interest existed in this paper.