Neuroprotective terpenoids from the leaves of Viburnum odoratissimum

Abstract

As a part of our ongoing search for neuroprotective compounds from natural products, two new iridoid glycosides, vibsansuspenside A-B (1-2), along with five known terpenoids (3-7), were isolated from the dry leaves of Viburnum odoratissimum. Their chemical structures were well determined by means of NMR spectroscopic data as well as HRESIMS analysis. All compounds were detected for their neuroprotective effects against H₂O₂-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). Among them, compound 3 displayed the most potent neuroprotective ability, and further investigation by Annexin V/PI and Western blot analysis demonstrated that compound 3 could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis.

Keywords:

• Viburnum odoratissimum
• Terpenoids
• neuroprotective activity
• apoptosis

Acknowledgements

Professor Y. Peng, Mrs. W. Li and Mr. Y. Sha of Shenyang Pharmaceutical University are appreciated for their help in measuring the HRESIMS and NMR data.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by National Natural Science Foundation of China [Grant No. 81703385].