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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 21
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Research Articles

Piptolinic acids F–J, five new lanostane-type triterpenoids from Piptoporus betulinus

Qosimjon KhalilovThe Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China; ;University of Chinese Academy of Sciences, Beijing, China; View further author information
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Liya LiInstitute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, ChinaView further author information
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Yushuang LiuThe Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China; ;University of Chinese Academy of Sciences, Beijing, China; View further author information
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Zeynep TohtahonThe Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China; ;University of Chinese Academy of Sciences, Beijing, China; View further author information
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Xiaoyu ChenThe Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China; ;University of Chinese Academy of Sciences, Beijing, China; View further author information
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Haji Akber AisaThe Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China; ORCID Iconhttp://orcid.org/0000-0003-4652-6879View further author information
ORCID Icon &
Tao YuanThe Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-7746-3714View further author information
ORCID Icon show all
Pages 3044-3051 | Received 16 Jul 2018, Accepted 22 Aug 2018, Published online: 26 Oct 2018
 
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Abstract

Five new lanostane-type triterpenoids, named piptolinic acids F − J (1–5), as well as seven known analogues (6–12), were isolated from methanolic extract of the fruiting bodies of Piptoporus betulinus. Compounds 1–4 were 24-methyl-lanostane triterpenoids, while compound 5 was a 3,4-seco-lanostane derivative. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR, and HRESIMS). Cytotoxicity evaluation indicated that compound 6 exhibited moderate cytotoxic activity against human melanoma cell line A-375 (IC50 = 42.8 μM) and human renal carcinoma cell line 786-O (IC50 = 56.5 μM).

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (U1703331, 81773998, 21502222), Xinjiang Key Research and Development Program (2016B03038-3), and the Recruitment Program of Global Experts (to Yuan), China.

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