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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 21
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Research Articles

Two new sesquiterpenoids from the marine-sediment-derived fungus Trichoderma harzianum P1-4

Sheng-Tao FangChinese Academy of Sciences, Yantai Institute of Coastal Zone Research, Yantai, ChinaView further author information
,
Ying-Jie WangChinese Academy of Sciences, Yantai Institute of Coastal Zone Research, Yantai, ChinaView further author information
,
Xin-Yue MaChinese Academy of Sciences, Yantai Institute of Coastal Zone Research, Yantai, ChinaView further author information
,
Xiu-Li YinChinese Academy of Sciences, Yantai Institute of Coastal Zone Research, Yantai, ChinaView further author information
&
Nai-Yun JiChinese Academy of Sciences, Yantai Institute of Coastal Zone Research, Yantai, ChinaCorrespondence[email protected]
View further author information
Pages 3127-3133 | Received 21 May 2018, Accepted 07 Sep 2018, Published online: 06 Nov 2018
 
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Abstract

Three cyclonerane sesquiterpenoids, including the known cyclonerodiol (1), together with its new derivatives, (10E)-12-acetoxy-10-cycloneren-3,7 -diol (2) and 12-acetoxycycloneran-3,7-diol (3) were isolated from the cultures of marine-sediment-derived fungus Trichoderma harzianum P1-4. The structures of the new compounds (2 and 3) were elucidated based on extensive spectroscopic methods (1D/2D NMR and HR-MS) and optical rotation analysis.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Financial support from the Natural Science Foundation for Distinguished Young Scholars of Shandong Province (JQ201712), National Natural Science Foundation of China (31670355), Key Cutting-Edge Research Program of the Chinese Academy of Sciences (QYZDB-SSW-DQC013) is gratefully acknowledged.

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