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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 21
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Short Communications

New benzyl-aporphine alkaloids from Thalictrum cultratum

Wenjia KangKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China
,
Jianyong LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China
,
Dahong LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China
,
Zhanlin LiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. ChinaORCID Iconhttp://orcid.org/0000-0001-5306-3396
ORCID Icon,
Shengshuang ChenKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China
,
Huiming HuaKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. ChinaCorrespondence[email protected] [email protected]
&
Jiao BaiKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China; ;School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. ChinaCorrespondence[email protected] [email protected]
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Pages 3176-3179 | Received 01 Aug 2017, Accepted 11 Sep 2018, Published online: 22 Dec 2018
 
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Abstract

Two new rare benzyl-aporphine alkaloids, thaliculine (1) and 6a,7-dehydrothaliculine (2), were isolated from the roots of Thalictrum cultratum Wall. Their structures were determined based on spectroscopic analysis including 1D, 2D NMR, and HR-ESI-MS. The stereochemistry of 1 was assigned by ECD spectroscopy. Compound 1 exhibited weak cytotoxicity against HL-60 cell line with IC50 value of 31.40 μM.

Acknowledgments

This work was supported by the Program for Innovative Research Team of the Ministry of Education and the Program for Liaoning Innovative Research Team in University.

Disclosure statement

No potential conflict of interest was reported by the authors.

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