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Abstract
A new naturally occurring trinoreudesmane sesquiterpene, artahongkongol A (1), together with seven known eudesmane sesquiterpenes (2−8), was isolated from the stems and leaves of Artabotrys hongkongensis Hance. Among them, 1 is a rare trinoreudesmane sesquiterpene containing 12 carbon atoms on the carbon skeleton. All known compounds (2−8) were isolated from the genus Artabotrys for the first time. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1−8 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.57 to 15.68 μM.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This work was financially supported by the National Natural Science Foundation of China (Nos. 31360069, 21302181, 21662011 and 31660097), the Key Research and Development Project of Haikou (No. 2017050), the Program for Innovative Research Team in University (No. IRT-16R19), the Special Project of the Central Government for the Development of Local Science and Technology (No. ZY2018HN07) and the Opening Foundation of State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China (CMEMR2014-B06).