A new aryldihydronaphthalene-type lignan and other metabolites with potential anti-​inflammatory activities from Corispermum mongolicum Iljin

Abstract

One new aryldihydronaphthalene-type lignan (1) together with eight known lignans (2-4, 7–11) as well as two caffeic-acid dimers (5, 6) were isolated from an ethanol extract of the whole plant of Corispermum mongolicum Iljin (Chenopodiaceae). The chemical structures of these compounds were determined from 1D and 2D NMR and HR-ESI-MS spectra, and results were compared with data from the literature. This study is the first demonstration of nine compounds (2 and 4–11) isolated from the Chenopodiaceae family, with one of these (3) from the genus Corispermum. Anti-inflammatory effects of the isolated compounds were evaluated in terms of inhibition of production of nitric oxide, tumour necrosis factor-α, and interleukin-6 in lipopolysaccharide-induced RAW 264.7 cells.

Keywords:

• Corispermum mongolicum Iljin
• Chenopodiaceae
• lignan
• anti-inflammatory activity

Acknowledgements

This work was supported by the National Natural Science Foundation of China [grant number 81760627], [grant number 81660699] and [grant number 81660579]. We thank Arshad Makhdum, PhD, from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.