A new aliphatic ester of hydroxysalicylic acid from fermented Carica papaya L. preparation with a potential hair growth stimulating activity

Abstract

An aliphatic ester of hydroxysalicylic acid (6), reported for the first time from a natural source in addition to five known compounds were isolated from the fermented Carica papaya L. preparation, a commercialized functional food. The known compounds were identified as 5-hydroxymethylfurfuraldehyde (1), trans-caffeic acid (2), butyl 4-hydroxybenzoate (butylparaben) (3), lycopene (4), benzyl isothiocyanate (5). Compounds 1 and 3 were reported for the first time from Papaya fruits through this study. The new compound showed a moderate antioxidant activity and a potent hair growth stimulating activity in vitro.

Graphical Abstract

Keywords:

• Carica papaya L.
• fermented preparation
• anti-oxidant
• hair growth

Acknowledgments

We acknowledge the help of CARICA CELAPI Co., Ltd. (Japan) for providing the material used for the study. The authors are much obliged to Ms. Noriko Yazawa for measurement of Bruker DRX 600 NMR spectrometer. We would like to thank Mr. Toshio Nishi, Evaluation Center of Materials Properties and Function, IMCE, Kyushu University for measurement of HR-FAB-MS. This work was partially supported by the Implementation of Projects to Nurture New Biotech Start-ups in Fukuoka Prefecture from Kurume Research Park Co., Ltd.

Disclosure statement

No potential conflict of interest was reported by the authors.