Briarane-type diterpenoids from the Vietnamese gorgonian Junceella fragilis

Abstract

Ten briarane-type diterpenoids (1–10), including one new stereoisomer 17-epi-junceellolide B (1), were isolated from the MeOH extract of the Vietnamese gorgonian Junceella fragilis. Their structures were elucidated by spectroscopic experiments including 1D and 2D NMR, and HR-QTOF-MS. In addition, the in vitro cytotoxic activity against eight human cancer cell lines (LNCaP, HepG2, KB, MCF-7, SK-Mel2, HL-60, LU-1 and SW480) of all isolated compounds was evaluated by SRB assays.

Keywords:

• Junceella fragilis
• gorgonian
• briarane
• cytotoxic activity

Acknowledgements

The authors are grateful to the Institute of Chemistry, VAST for measurement of the NMR spectra, Prof. Do Thi Thao, Institute of Biotechnology, VAST for evaluation of the cytotoxicity and Dr. Bui Huu Tai, Institute of Marine Biochemistry, VAST for measurement of the CD and HR-QTOF mass spectra.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research is funded by a grant from Vietnam Academy of Science and Technology (code: VAST.TĐ.DLB.02/16-18).