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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 7
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Research Articles

Pestalotiopisorin B, a new isocoumarin derivative from the mangrove endophytic fungus Pestalotiopsis sp. HHL101

Zhiyong XuKey Laboratory of Tropical Biological Resources of Ministry of Education, College of Material and Chemical Engineering, Hainan University, Haikou, P. R. China; ;Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, P. R. ChinaView further author information
,
Xi WuKey Laboratory of Tropical Biological Resources of Ministry of Education, College of Material and Chemical Engineering, Hainan University, Haikou, P. R. China; View further author information
,
Gang LiKey Laboratory of Tropical Biological Resources of Ministry of Education, College of Material and Chemical Engineering, Hainan University, Haikou, P. R. China; View further author information
,
Zhao FengKey Laboratory of Tropical Biological Resources of Ministry of Education, College of Material and Chemical Engineering, Hainan University, Haikou, P. R. China; View further author information
&
Jing XuKey Laboratory of Tropical Biological Resources of Ministry of Education, College of Material and Chemical Engineering, Hainan University, Haikou, P. R. China; ;Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, P. R. ChinaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6201-5318View further author information
ORCID Icon
Pages 1002-1007 | Received 04 Sep 2018, Accepted 21 Oct 2018, Published online: 09 Jan 2019
 
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Abstract

A new isocoumarin derivative pestalotiopisorin B (1), along with six known compounds, (R)-(-)- mellein methyl ether (2), pestalotiopyrone G (3), (R)-mevalonolactone (4), pestalotiollides A–B (5–6) and pestalotiopsol A(7) were isolated from Pestalotiopsis sp., an endophytic fungus obtained from Chinese mangrove plant Rhizophora stylosa. Their structures were elucidated unambiguously by the comprehensive analysis of extensive spectroscopic data. Compound 1 exhibited modest antibacterial activity against Escherichia coli and Pseudomonas aeruginosa with 12.5 μg/ml, 50 μg/ml, respectively. Compound 4 showed moderate calcineurin inhibitory activity towards p-nitrophenyl phosphate (IC50 =134.29 ± 5.377 μM).

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Additional information

Funding

This study was funded by grants from the National Natural Science Foundation of China (No. 81660584), Key Research Program of Hainan Province (ZDYF2017099) and the Innovative Research Team Grant of the Natural Science Foundation of Hainan University (hdkytg201705) are gratefully acknowledged.

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