Toonapolyynes A–D, new polyynes from Toona ciliata

Abstract

Phytochemical investigation on the leaves and twigs of Toona ciliata has led to the isolation of four new polyynes (1–4) and two knowns (5 and 6). Their structures were determined by extensive spectroscopic analysis (MS, UV, IR, and NMR) and Mosher’s method. All compounds were evaluated for their inhibitory activities against HepG2 human tumor cell line but were inactive.

Keywords:

• Toona ciliata
• Meliaceae
• Mosher’s method
• polyynes

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work is supported by the National Natural Science Foundation of China (Nos. 81402813 and 81573302), the Guangdong Natural Science Funds for Distinguished Young Scholar (No. 2014A030306047), and the Science and Technology Planning Project of Guangdong Province, China (No. 2015A020211007).