Chemical characterization of constituents from Polygonatum cyrtonema Hua and their cytotoxic and antioxidant evaluation

Abstract

Twenty-four compounds were isolated from the roots of Polygonatum cyrtonema Hua, including a new octopamine dimer, named trans-bis(N-feruloyl)octopamine (1). The structure was established on the basis of spectroscopic and chemical methods. All the extracts and compounds were evaluated for cytotoxic and antioxidant activities by using MTT and chemiluminescence assay. The extracts showed activity against MCF-7 and HepG-2 cell lines from IC₅₀ 0.30 to 1.01 mg mL⁻¹. Compound 3 exhibited activity against HepG-2 cell lines with IC₅₀ 8.99 μM. Compound 7 exhibited activity against Hela cell lines with IC₅₀ 2.53 μM and BGC-823 cell lines with IC₅₀ 7.77 μM. Moreover, compound 7 showed antioxidant with IC₅₀ 12 µM compared to the positive control with IC₅₀ 77 µM. Compound 16 exhibited activity against HepG-2 cell lines with IC₅₀ 1.05 μM and MCF-7 cell lines with IC₅₀ 1.89 μM. These results indicated that this plant might be potential in natural medicine and healthy food.

Graphical Abstract

Keywords:

• Polygonatum cyrtonema Hua
• chemical constituents
• cytotoxic
• antioxidant

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Standardization Construction in TCMs of China under Grant ZYBZH-Y-HUN-23; National Natural Science Foundations of China under Grant 81673579, 81703819 and 81874369; Hunan science and technology project funds under Grant HHS2017zy03, 2018SK2119 and kq1706055; and Graduate science and technology innovation projects in 2017 under Grant CX2017B443.