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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 8
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Research Articles

Citriperazines A-D produced by a marine algae-derived fungus Penicillium sp. KMM 4672

Anton Nikolaevich YurchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6816-3605
ORCID Icon,
Dmitry V. BerdyshevG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia;
,
Olga F. SmetaninaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia;
,
Elena V. IvanetsG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia; ORCID Iconhttp://orcid.org/0000-0002-4610-1718
ORCID Icon,
Olesya I. ZhuravlevaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia; ;Laboratory of Biologically Active Compounds, Far Eastern Federal University, Vladivostok, Russia;
,
Anton B. RasinG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia;
,
Yuliya V. KhudyakovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia;
,
Roman S. PopovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia;
,
Sergey A. DyshlovoyG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia; ;Laboratory of Biologically Active Compounds, Far Eastern Federal University, Vladivostok, Russia; ;Laboratory of Experimental Oncology, Department of Oncology, Haematology and Bone Marrow Transplantation, Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyCorrespondence[email protected]
,
Gunhild von AmsbergLaboratory of Experimental Oncology, Department of Oncology, Haematology and Bone Marrow Transplantation, Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyCorrespondence[email protected]
&
Shamil Sh. AfiyatullovG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia;
show all
Pages 1118-1123 | Received 06 Sep 2018, Accepted 22 Nov 2018, Published online: 19 Jan 2019
 
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Abstract

Four new diketopiperazine alkaloids, citriperazines A-D were isolated from algae-derived Penicillium sp. KMM 4672. The structures of compounds 1–4 were determined using spectroscopic methods. The absolute configurations of compounds 1 and 4 were established by comparison of calculated and experimental ECD spectra. The cytotoxicity of compounds 1–4 against several human prostate cell lines was evaluated.

Graphical Abstract

Acknowledgements

The study was supported by the Russian Foundation for Basic Research (Grant No 18-34-00621).

Disclosure statement

No potential conflict of interest was reported by the authors.

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