Four C-geranyl flavonoids from the flowers of Paulownia fortunei and their anti-inflammatory activity

Abstract

Four new C-geranyl flavonoids, paulownione D-G (1–4) were isolated from the 50% acetone-H₂O extract of the flowers of Paulownia fortunei. The structures of the compounds were determined by extensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR). All of the compounds (1–4) exhibited potent protection effects in H9c2 cardiocytes against the lipopolysaccharide (LPS)-induced inflammation.

Graphical abstract

Keywords:

• Paulownia fortunei
• C-geranyl flavonoids
• anti-inflammatory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Central Government Guide Local Science and Technology Development Funds (14104349).