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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 23
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Research Articles

Two new alkaloids from the tubers of Corydalis ambigua subsp. amurensis and their anti-proliferative activity

Zhihui LiuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China; ;Development and Utilization Key Laboratory of Northeast Plant Materials Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
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Zhenru MiSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China; ;Development and Utilization Key Laboratory of Northeast Plant Materials Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
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Panpan WangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China; ;Development and Utilization Key Laboratory of Northeast Plant Materials Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
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Sheng ChangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China; ;Development and Utilization Key Laboratory of Northeast Plant Materials Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
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Na HanSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China; ;Development and Utilization Key Laboratory of Northeast Plant Materials Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
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Jun YinSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China; ;Development and Utilization Key Laboratory of Northeast Plant Materials Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected]
Pages 3305-3312 | Received 28 Sep 2018, Accepted 22 Dec 2018, Published online: 25 Mar 2019
 
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Abstract

Two new alkaloids, including one benzophenanthridine type, dehydroambiguanine A (1) and one isoquinoline type, ambiguanine J (2) together with four (3–6) known alkaloids were isolated from the n-butanol fraction of Corydalis ambigua subsp. amurensis. Their structures were elucidated by comprehensive spectroscopic methods including HR-ESIMS and NMR, and the absolute configuration of compound 1 was further confirmed by the quantum ECD calculations. In addition, all isolated alkaloids (1–6) were determined their anti-proliferative effects of on A549 and HCT 116 cell by colorimetric MTT assay. Among them, Compounds 1 and 4 exhibited anti-proliferative activity on HCT 116 cell line with the IC50 value at 49.8 ± 4.79, and 89.2 ± 1.86 μM, respectively. Compounds 2 and 5 showed mild anti-proliferative activity against A549 cell with IC50 values at 60.2 ± 10.7, and 89.2 ± 12.9 μM, respectively. Their preliminary structure-activity relationship was also discussed.

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