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Abstract
A chemical investigation of Cynanchum mongolicum (Maxim.) Kom. identified 8 compounds. On the basis of spectroscopic data, they were determined to be 3 alkaloids and 5 sinapoyl esters, among which were two previously undescribed compounds (1 and 2). The inhibitory effects of the isolated compounds against four human tumor cell lines were evaluated in vitro by MTT assays, which revealed moderate inhibitory effects with IC50 values < 50 mM, in particularly, three antofine analogues have showed significant antitumor activities with IC50 values < 0.1 mM, which was obviously better than the 5-fluorouracil and potential to be used as cancer drugs.
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Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was supported by the National Key R&D Program of China (2017YFC1701200) and the National Natural Science Foundation of China (No. 81374061); the Program for Innovative Research Team of the Ministry of Education and Program for Liaoning Innovative Research Team in University.