Dendrobeaniamine A, a new alkaloid from the Arctic marine bryozoan Dendrobeania murrayana

Abstract

The new guanidine alkaloid Dendrobeaniamine A (1) was isolated from the organic extract of the Arctic marine bryozoan Dendrobeania murrayana. The chemical structure of 1 was elucidated by spectroscopic experiments, including 1D and 2D NMR and HRESIMS analysis. Compound 1 is a lipoamino acid, consisting of a C₁₂ fatty acid anchored to the amino acid arginine. The bioactivity of 1 was evaluated using cellular and biochemical assays, but the compound did not show cytotoxic, antimicrobial, anti-inflammatory or antioxidant activities

Graphical Abstract

Keywords:

• Arctic invertebrates
• bryozoans
• Dendrobeania murrayana
• bioprospecting
• marine secondary metabolites

Acknowledgements

The authors would like to thank Marbank for marine bryozoan collection, identification, and extraction. We also would like to acknowledge the department engineers Marte Albrigtsen and Kirsti Helland for the bioactivity experiments.

Disclosure statement

The authors declare no conflict of interest.