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Abstract
A new (1, grincamycin L) and two known (2 and 3) angucycline derivatives were obtained from the fermentation of deepsea-derived Streptomyces lusitanus OUCT16-27 strain. The structures of 1–3 were elucidated based on the LC-MS analysis together with 1D and 2D NMR data assignment. In the antibacterial assay, 1 and 2 exhibited moderate growth inhibitions against multi-drug resistant (MDR) strains of E. faecium, E. faecalis and S. aureus with the minimum inhibitory concentrations (MICs) of 3.12–6.25 µg/mL.
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Disclosure statement
The authors declare no conflict of interest.
Additional information
Funding
This research was supported by the National Natural Science Foundation of China under grants 21502180, 81561148012, 31570032 and 41506157, the NSFC-Shandong Joint Fund for Marine Science Research Centers under grants U1706206 and U1406403, and the Science and Technology Project of Qingdao under grant 17-3-3-44-nsh.