Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 15
Submit an article Journal homepage
262
Views
5
CrossRef citations to date
0
Altmetric
Research Articles

Perisomalien A, a new cytotoxic scalarane sesterterpene from the fruits of Periploca somaliensis

Khadijah A. JabalDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; ;Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia;
,
Hossam M. AbdallahDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; ;Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt;
,
Gamal A. MohamedDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; ;Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt;
,
Ibrahim A. ShehataDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; ;Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt;
,
Mohammad Y. AlfaifiFaculty of Science, Biology Department, King Khalid University, Abha, Saudi Arabia;
,
Serag Eldin I. ElbehairiFaculty of Science, Biology Department, King Khalid University, Abha, Saudi Arabia; ;Cell Culture Lab, Egyptian Organization for Biological Products and Vaccines (VACSERA Holding Company), Agouza, Giza, Egypt;
,
Abdulrahman A. KoshakDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia;
&
Sabrin R. M. IbrahimDepartment of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah, Saudi Arabia; ;Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, EgyptCorrespondence[email protected] [email protected]
 show all
Pages 2167-2172 | Received 17 Dec 2018, Accepted 29 Jan 2019, Published online: 05 Mar 2019
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

The CHCl3 fraction of MeOH extract of Periploca somaliensis (family Asclepiadaceae) fruits afforded a new scalarane sesterterpene, namely perisomalien A (1), along with lupeol acetate (2), β-amyrin (3), cycloart-23Z-ene-3β,25-diol (4), and β-sitosterol-3-O-β-D-glucopyranoside (5). Their chemical structures were established by various spectroscopic analyses, in addition to comparison with the formerly reported data. Moreover, the cytotoxic activity of these metabolites was assessed towards MCF-7, HepG2, and HCT-116 tumour cell lines using sulforhodamine B (SRB) assay. Compound 4 showed the most potent cytotoxic profile with IC50 9.0 µM towards MCF-7, compared to doxorubicin (IC50 0.18 µM). Also, 1 and 4 possessed the most potent effect towards HepG2 with IC50s 26.7 and 25.9 μM, respectively. In addition, all tested compounds showed cytotoxic effects with IC50 values ranging from 19.9 to 39.3 µM against HCT-116.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 861.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.