Abstract
Two new triterpenoid saponins, tomentoside T1 (1) and tomentoside T2 (2), together with eleven known compounds (3–13) were obtained from ethyl acetate extracts of Anemone tomentosa (Maxim.) Pei by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. The cytotoxic activity of all isolated saponins was evaluated on MDA-MB-231 and PC-3 cell lines. Compounds 5 and 7 showed significant cytotoxicity against with MDA-MB-231 cell and PC-3 cell with IC50 values of 3.73–4.21 μM and 3.53–5.37 μM, respectively.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.