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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 20
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Short Communications

Mycenolide A, new butenolide from a marine sediment-derived bacterium Streptomyces sp. 4054

, , , &
Pages 2986-2989 | Received 15 Dec 2018, Accepted 14 Mar 2019, Published online: 09 Apr 2019
 

Abstract

Streptomyces sp. 4054, isolated from marine sediments, produced a new butenolide, mycenolide A (1), along with five known butenolide derivatives (26). The structures of the compounds were established based on 1D- and 2D-NMR spectroscopic analysis, circular dichroism, and mass spectrometry data. The antimicrobial activity of the crude extract of the marine bacteria Streptomyces sp. 4054 was evaluated, showing good results against Bacillus subtilis and MRSA.

Acknowledgement

The authors are grateful to Michael LeBlanc for technical assistance.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by NSERC (Natural Sciences and Engineering Research Council of Canada) for funding.

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