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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 20
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Research Articles

A pair of new neo-clerodane diterpenoid epimers from the roots of Croton crassifolius and their anti-inflammatory

Dong-Bo ZhangShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; View further author information
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Zhi-Shu TangShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; Correspondence[email protected]
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Pei XieShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; View further author information
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Yan-Ni LiangShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; View further author information
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Jin-Gao YuShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; ORCID Iconhttp://orcid.org/0000-0003-0260-3334View further author information
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Zhen ZhangShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; View further author information
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Dong-Zhu DuanBao Ji University of Arts and Sciences, Baoji, P.R. China; View further author information
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Chun-Li CuiShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; View further author information
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Zhong-Xing SongShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; View further author information
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Li RenShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; View further author information
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Zheng WangShaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang, P.R. China; Correspondence[email protected]
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Dao-Geng YuChinese Academy of Tropical Agricultural Science, Tropical Crops Genetic Resources Institute, Danzhou, P.R. ChinaCorrespondence[email protected]
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Pages 2945-2951 | Received 21 Jan 2019, Accepted 22 Mar 2019, Published online: 13 May 2019
 
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Abstract

A pair of new neo-clerodane diterpenoid epimers, 3S-methoxyl-teucvin (1) and 3R-methoxyl-teucvin (2), were isolated from the Roots of Croton crassifolius. Their structures were completely established on the basis of spectroscopic methods, and the absolute configurations were determined by analysis of electronic circular dichroism (ECD) spectroscopy and X-ray diffraction analysis. Compounds 1 and 2 exhibited anti-inflammatory activities with IC50 values of 0.82 and 0.54 μM, respectively, while the IC50 value of dexamethasone as a positive control was found to be 0.14 μM.

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Program for National Natural Science Foundation of China [grant number 81703392]; the Key Research and Development Program of Shaanxi Province [grant number 2017SF-365]; the Natural Science Foundation of Shaanxi Provincial Department of Education (grant number 16JK1196).

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