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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 21
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Short Communications

Biological properties and chemical composition of essential oil from Nectandra megapotamica (Spreng.) Mez. leaves (Lauraceae)

Karoliny C. R. AlmeidaInstituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais, Pouso Alegre, MG, Brazil;
,
Bruna B. SilvaInstituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais, Pouso Alegre, MG, Brazil;
,
Cassia C. F. AlvesInstituto Federal de Educação, Ciência e Tecnologia Goiano, Rio Verde, GO, Brazil; ORCID Iconhttp://orcid.org/0000-0003-2004-3166
ORCID Icon,
Tatiana M. VieiraDepartamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil;
,
Antônio E. M. CrottiDepartamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil; ORCID Iconhttp://orcid.org/0000-0001-6047-4871
ORCID Icon,
João M. SouzaNúcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil;
,
Carlos H. G. MartinsNúcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil; ORCID Iconhttps://orcid.org/0000-0001-8634-6878
ORCID Icon,
Arthur B. RibeiroNúcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil;
,
Iara S. SquarisiNúcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil;
,
Denise C. TavaresNúcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil; ORCID Iconhttps://orcid.org/0000-0003-4646-5914
ORCID Icon,
Laura dos S. BernabéNúcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil;
,
Lizandra G. MagalhãesNúcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil; ORCID Iconhttps://orcid.org/0000-0003-2959-6752
ORCID Icon &
Mayker L. D. MirandaInstituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro, Uberlândia, MG, BrazilCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-4689-572X
ORCID Icon show all
Pages 3149-3153 | Received 05 Dec 2018, Accepted 06 Apr 2019, Published online: 14 May 2019
 
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Abstract

Nectandra megapotamica is a tree species that naturally occurs in the Atlantic Forest, Brazil. This paper aims to investigate the chemical composition and in vitro antibacterial, antileishmanial and antiproliferative activities of essential oil from N. megapotamica leaves (NM-EO). It displayed high antibacterial activity against Streptococcus mutans, S. sobrinus, Prevotella nigrescens and Bacteroides fragilis. NM-EO also exhibited high antileishmanial activity against promastigote forms of Leishmania amazonensis. Its antiproliferative activity was evaluated against the following cells: GM07429A (normal cell), MCF-7 (human breast adenocarcinoma), HeLa (human cervical adenocarcinoma) and M059J (human glioblastoma). Its major components, which were determined by GC-FID and GC-MS, were α-bisabolol (13.7%), bicyclogermacrene (10.9%), (E,E)-farnesene (10.6%), Z-caryophyllene (9.5%) and (E)-β-farnesene (7.0%). These results suggest that N. megapotamica, a Brazilian plant, shows initial evidence of a new and alternative source of substances of medicinal interest.

Graphical Abstract

Disclosure statement

No potential conflict of interest is reported by the authors.

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