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Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 21
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Research Articles

Populeuphrines A and B, two new cembrane diterpenoids from the resins of Populus euphratica

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Pages 3108-3116 | Received 29 Jan 2019, Accepted 07 Apr 2019, Published online: 02 Jul 2019
 

Abstract

Two new cembrane diterpenoids, named populeuphrines A and B (1 and 2), together with three known analogues (35) were isolated from the resins of Populus euphratica. The planar structures and relative configurations of 1 and 2 were elucidated by detailed 1 D and 2 D NMR spectroscopic analyses. The absolute configurations of 1 and 2 were determined by X-ray diffraction analysis and quantum chemical computation. Biological activities of all the isolates against proliferation of human cancer cells and umbilical cord mesenchymal stem cells were evaluated.

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the National Science Fund for Distinguished Young Scholars (81525026) and National Key Research and Development Program of China (2017YFA0503900). We thank Lin-Hai Jiang and Hong-Bo Yang at Instrumental Analysis Center of Shenzhen University (Xili Campus) for their assistance with spectroscopic data collection.

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