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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 1
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Research Articles

Diterpenoid and triterpenoid glycosides from Clinopodium chinense

Ling-Xia QuSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China; ;School of Pharmacy, Wenzhou Medical University, Wenzhou, China; ;Health-cultivation Laboratory of the Ministry Education, Beijing University of Chinese Medicine, Beijing, China; ;Health-cultivation Laboratory of the Beijing, Beijing University of Chinese Medicine, Beijing, ChinaView further author information
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Yong-Qiao LiuSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China; ;Health-cultivation Laboratory of the Ministry Education, Beijing University of Chinese Medicine, Beijing, China; ;Health-cultivation Laboratory of the Beijing, Beijing University of Chinese Medicine, Beijing, ChinaView further author information
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Yang WangSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China; ;Health-cultivation Laboratory of the Ministry Education, Beijing University of Chinese Medicine, Beijing, China; ;Health-cultivation Laboratory of the Beijing, Beijing University of Chinese Medicine, Beijing, ChinaView further author information
,
Hong WangSchool of Pharmacy, Wenzhou Medical University, Wenzhou, China; View further author information
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Xue-Li HuangSchool of Pharmacy, Wenzhou Medical University, Wenzhou, China; View further author information
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Mei-Ling ZhangSchool of Pharmacy, Wenzhou Medical University, Wenzhou, China; View further author information
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Yong-Xiao MouSchool of Pharmacy, Wenzhou Medical University, Wenzhou, China; View further author information
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Tun-Hai XuSchool of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China; ;Health-cultivation Laboratory of the Ministry Education, Beijing University of Chinese Medicine, Beijing, China; ;Health-cultivation Laboratory of the Beijing, Beijing University of Chinese Medicine, Beijing, ChinaCorrespondence[email protected]
View further author information
&
Yin-Di ZhuSchool of Pharmacy, Wenzhou Medical University, Wenzhou, China; Correspondence[email protected]
View further author information
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Pages 25-33 | Received 18 Feb 2019, Accepted 19 Apr 2019, Published online: 28 May 2019
 
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Abstract

Two new compounds, including a diterpenoid glycoside (1) and a triterpenoid glycoside (6), along with six known compounds were isolated from Clinopodium chinense. The structures of the new compounds were determined on basis of extensive spectral analysis and chemical method. Compounds 1–8 were evaluated for their insulin resistance effect and cytotoxic activity against the A549 and HepG2 cancer cell lines. None of the compounds were cytotoxic (IC50 > 100 μM), while compounds 1–3 and 5 showed the activity of ameliorating insulin resistance in HepG2.

GRAPHICAL ABSTRACT

Disclosure statement

The authors declare no competing financial interest.

Additional information

Funding

This work was supported by grants (No. 81703689) from the National Natural Sciences Foundation of China and Wenzhou Medical University Research Initiation Fund (No. QTJ16015).

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