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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 6
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Research Articles

New cytotoxic biflavones from Selaginella doederleinii

Li-Fei LiuXiangya Hospital of Central South University, Changsha, PR China; ;Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China; View further author information
,
Hui-Hui SunXiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China; View further author information
,
Jian-Bing TanXiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China; View further author information
,
Qi HuangXiangya Hospital of Central South University, Changsha, PR China; View further author information
,
Fei ChengXiangya Hospital of Central South University, Changsha, PR China; ;Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha, PR ChinaView further author information
,
Kang-Ping XuXiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China; View further author information
,
Zhen-Xing ZouXiangya Hospital of Central South University, Changsha, PR China; ;Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China; Correspondence[email protected]
View further author information
&
Gui-Shan TanXiangya Hospital of Central South University, Changsha, PR China; ;Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China; Correspondence[email protected]
View further author information
 show all
Pages 930-936 | Received 27 Feb 2019, Accepted 23 Apr 2019, Published online: 21 May 2019
 
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Abstract

Three new biflavones, apigenin-(3′,8″)-chrysin (1), (2S)-2,3-Dihydroametoflavone 5,4′-dimethyl ether (2), and (2S)-5″,7″-Dihydroxy-2″-phenoxychromonyl-(4′″,3′)-naringenin (3), together with seven known biflavones (4–10) were isolated from the 75% EtOH extract of Selaginella doederleinii. The structures of new compounds were established by application of spectroscopic methods, including 1D and 2D NMR, HRMS, and CD measurements. In addition, all new compounds were evaluated for their cytotoxic potential against three human cancer cell lines A549, MCF-7, and SMMC-7721 in vitro. Compound 2 exhibited potent cytotoxic activity with IC50 values ranging from 6.35 to 10.18 μM.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [grant number 31700303], Natural Science Foundation of Hunan Province [grant number 2018JJ3839].

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