Sesquiterpenoids and meroterpenoids from a mangrove derived fungus Diaporthe sp. SCSIO 41011

Abstract

One new sesquiterpenoid, 1-methoxypestabacillin B (1), along with one known sesquiterpenoid (2) and six known chrodrimanin-type meroterpenoids (3‒8) were obtained from the solid cultures of a mangrove endophytic fungus Diaporthe sp. SCSIO 41011. Their structures including the absolute configuration at C-6 of compound 1, were determined by extensive spectroscopic analyses and ECD calculations. Meanwhile, the X-ray crystal structures and absolute configurations of two previously reported chrodrimanins E (3) and H (6), are described for the first time. All the compounds were examined for HIV latency-reversal and anti-influenza A virus activities.

Graphical Abstract

Keywords:

• Sesquiterpenoids
• chrodrimanins
• marine fungi
• Diaporthe sp

Acknowledgements

We are grateful to Z. Xiao, A. Sun, X. Ma and Y. Zhang in the analytical facilities of SCSIO.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work is financially supported in part by the National Natural Science Foundation of China (No.21772210), Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (No.2018006), the Scientific Research Foundation of Institute of Marine Drugs, GUCM (2018ZD005-A17), China Postdoctoral Science Foundation (No.2016M602920XB); Key Project of Science and Technology Department of Guangxi (AB16380009), Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province (GDME-2018C010), Project from Institution of South China Sea Ecology and Environmental Engineering, CAS (ISEE2018PY04).