Abstract
One new indole alkaloid derivative, 5,6-dioxo-11-hydroxy voacangine (1) together with four known compounds (2-5), were isolated from the fruits of Tabernaemontana inconspicua Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR, HRESI-MS, and a comparison with the literature. The new compound was found to be cytotoxic on human breast cancer MDA-MB 231 cells with IC50 values of 3.35 µM and 2.19 µM after 24 and 48 hours, respectively.
GRAPHICAL ABSTRACT
Acknowledgements
EMN is very grateful to Chinese Academy of Sciences President’s International Fellowship Initiative for its financial support. We thank Prof. Dr. Dr. h.c. Michael Spiteller and Pr. Marie-Christine Lallemand for performing NMR analyses.
Disclosure statement
No potential conflict of interest was reported by the authors.