Plinia cauliflora (Mart.) Kausel: toxicological assays, biological activities, and elemental analysis of organic compounds

Abstract

Jaboticaba, Plinia cauliflora (Mart.) Kausel, is a Brazilian berry traditionally used in folk medicine as treatment for some health conditions. Phenolic compounds such as flavonoids and anthocyanins have previously been detected in the fruit. This current study aimed to evaluate the toxicological effects of jaboticaba peel extract (JPE) on Artemia salina, L929, and MDA-MB-231 cell lines. Besides, JPE antioxidant, acetylcholinesterase, and antifungal activities, and elemental analysis CHNS were also tested. JPE had moderate toxicity (LD₅₀ = 360.92 μg mL⁻¹) on A. salina, non-toxic effect on L929 cell line, and decreased the viability of cancer cell line MDA at 1,000 µg mL⁻¹ and 500 µg mL⁻¹ concentrations. The antioxidant activity toward 2,2-diphenyl-1-picrylhydrazyl (DPPH) performed IC₅₀ = 37.45 ± 0.17 µg mL⁻¹, whereas 45.7% of acetylcholinesterase activity was inhibited. By its elemental composition, JPE is an alternative food supplement and dermocosmetic component. Antifungal potential toward Candida strains was not observed.

GRAPHICAL ABSTRACT

Keywords:

• Jaboticaba
• cell viability
• antiproliferative
• antioxidant capacity
• acetylcholinesterase activity
• elemental analysis

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

The authors gratefully acknowledge PROPESQ/UFJF, FAPEMIG, CNPq and CAPES.