Aristololactam alkaloids from the roots of Dasymaschalon rostratum

Abstract

A novel aristololactam alkaloid, dasymalactam A (1), together with nine known analogues (2–10), were isolated from the roots of Dasymaschalon rostratum. Their structures were elucidated by IR, NMR and MS spectrums and comparisons with data reported in the literature. All compounds demonstrated weak cytotoxicity against Hela, MCF-7, A-549, MGC-803, and COLO-205 human cancer cell lines.

Keywords:

• Dasymaschalon rostratum
• annonaceae
• aristololactam
• anticancer activity

Disclosure statement

No potential conflict of interest has been reported by the authors.

Additional information

Funding

This work was supported by Key R&D Projects in Hainan Province - Social Development (Grant No. ZDYF2018164), the Project for Scientific Research in Hainan Institution of Higher Learning (Grant No. Hnky2017-87), International S&T cooperation Program of China (ISTCP) (Grant No. 2014DFA40850) and the National Natural Science Foundation of China (Grant No. 21362009, 81360478).